Nederlandse Vereniging voor Klinische Chemie en Laboratoriumgeneeskunde
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Onderzoekslijn 146 Desmosine als biomarker voor elastine degradatie
Categorie Analytisch e. Vlamfotometrie, AAS, massaspectrometrie
Trefwoord 1 COPD
Trefwoord 2 desmosine
Omschrijving Chronic obstructive pulmonary disease (COPD) is characterized by the degradation of elastin, the major insoluble protein of lung tissues. Its degradation gives rise to desmosine (DES) and isodesmosine (IDS) in body fluids. DES and IDS are promising biomarkers for estimating activity of elastin degradation, although their clinical validity and utility remain uncertain due to the lack of reliable and sensitive
assays. This research line is to develop and validate a stable isotope dilution LC-MS/MS method for measurement of DES and IDS in urine and plasma.This method can be used to assess the potential of DES and IDS as biomarkers for estimating disease activity in COPD
and the effect of therapeutic interventions.

Onderzoeksleider laboratorium Dr. J.M.W.(Jody) van den Ouweland
Mede-onderzoeksleiders
Instituut Canisius-Wilhelmina Ziekenhuis Nijmegen
Periode 1-2013 - 1-2017
Projecten