PPO Database - projecten

Zoek op naar

Onderzoekslijnen		Alle projecten		Alle publicaties en voordrachten		Instituten

Project 79	Identificatie van vroege signalen van geneesmiddel geïnduceerde bloedbeeldafwijkingen dmv koppeling van klinische medicatie en laboratorium data / Identification of early-warning signals for drug-induced blood dyscrasias by linkage of drug exposition
Onderzoekslijn	AACD: Applied analytics of clinical data
Omschrijving	The aim of this project is threefold: 1. To establish an infrastructure of automated relational databases comprising clinical (e.g. medication, laboratory) and administrative (e.g. hospital discharge diagnoses, procedures) data that can be used for clinical epidemiologic research 2. To investigate the added value of clinical laboratory data in pharmacoepidemiologic research, using drug-induced thrombocytopenia as a model. 3. To investigate whether (new) haematological parameters can be used as early warning markers for drug-induced blood dyscrasias, using drug-induced thrombocytopenia as a model.
Projectleider	Prof.dr. W.W.(Wouter) van Solinge
Instituut	Universitair Medisch Centrum Utrecht locatie AZU Utrecht
Trefwoorden	NL: vroege markers, bijwerkingen, klinisch chemische parameters, hematologische parameters, databases, verbetering van zorg, vernieuwing van zorg, farmacovigilantie
Status	Afgesloten
Periode	2-2005 - 2-2009
Partners	- Afdeling Farmacoepidemiologie en Farmacotherapie, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculteit Farmaceutische Wetenschappen, Universiteit Utrecht - Afdeling Klinische Farmacie, UMC Utrecht
Medewerkers	Drs. Maarten J. ten Berg Dr. Patricia M.L.A. van den Bemt Dr. Albert Huisman Prof. Dr. A.F.A.M. (Fred) Schobben Prof. Dr. A.C.G. (Toine) Egberts
Financiering	1e Geldstroom - Intern
Publicaties	Linking laboratory and medication data: new opportunities for pharmacoepidemiological research. Changes in Hematological Parameters After Switching Treatment of HIV-Infected Patients from Zidovudine to Abacavir or Tenofovir DF. Laboratory markers in drug safety research: studies on drug-induced thrombocytopenia Compliance with platelet count monitoring recommendations and management of possible heparin-induced thrombocytopenia in hospitalized patients receiving low-molecular-weight heparin. Thrombocytopenia in adult cancer patients receiving cytotoxic chemotherapy: results from a retrospective hospital-based cohort study. Instructions on laboratory monitoring in 200 drug labels. Information comparison of the effects of drugs on laboratory tests in drug labels and Young`s book. Rituximab-induced thrombocytopenia: a cohort study.