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Project 276 Invloed van vitamine K op elastine degradatie in COPD
Onderzoekslijn Desmosine als biomarker voor elastine degradatie
Omschrijving Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Although cigarette smoking is the most important risk factor, not all smokers develop the disease. Previous studies have suggested a role for fat soluble vitamins D and A in the pathogenesis of COPD. To the best of our knowledge vitamin K has never been studied as a potential causative factor. In the lungs of COPD patients there is an imbalance between proteases degrading connective tissue components like elastin, and antiproteases protecting against this degenerative process. Desmosine only occurs in elastin and therefore its plasma levels reflect the rate of elastin degradation. Elastin has high affinity for calcium and during aging the calcium concentration in elastin rises. Elastin degradation and calcification are inter-related since degraded elastin is more susceptible to calcification and vice versa. Matrix Gla protein (MGP) is a vitamin K dependent protein and the strongest natural inhibitor of elastin calcification. The hypothesis is that COPD patients have lower vitamin K status than smokers without COPD and that plasma desmosine levels are inversely associated with vitamin K status.
Projectleider Dr. J.M.W.(Jody) van den Ouweland
Instituut Canisius-Wilhelmina Ziekenhuis Nijmegen
Trefwoorden vitamin K elastine COPD desmosine
Status Lopend
Periode 1-2015 - 1-2025
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Medewerkers
Financiering 1e Geldstroom - Intern

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